Business
Estate Planning Essentials: Understanding the Ramifications of Not Creating a Will
The realities of death aren’t something most people are accustomed to frequently discussing, but certain things like estate planning and creating a will are crucial for everyone to consider. Death is inevitable for all of us, and the ramifications of failing to plan ahead often prove significant.
“While we may not like to think about death, it’s crucial to plan for it,” says Attorney John Wood of Grant Park Legal Advisors. “Those who think they don’t need a will may want to consider the consequences of going without one.”
What is a will?
There is a common misconception that wills are only meant for those who are incredibly wealthy or possess a significant amount of assets that will have to be divided among their relatives. According to Wood, however, everyone can benefit from a will.
“A will is simply a legal document that outlines your wishes regarding the distribution of your assets after your death,” Wood explains. “If you pass away without one, your assets may not go to the people you intended. Instead, the laws of intestacy come into play to determine who your assets are left to.”
The laws of intestacy
The laws of intestacy vary from state to state, but in general, they will prioritize immediate family members, such as spouses and children. Problems arise when a person may have specific ideas or desires on who should receive their assets but fail to have the legal documentation to make their wishes known.
“Each person has unique situations, and wills account for these circumstances,” Wood says. “Perhaps they’re not particularly close to their children, or have no children, and wish for their assets to go to nieces and nephews, or they have no family at all and want what they leave behind to go to a favorite charity. Whatever the case, these circumstances should be outlined legally so a person’s last wishes can be fulfilled.”
Putting the future of minor children in jeopardy
No one likes to think about dying and leaving behind young children, but it happens. “If you have children who are still minors, creating a will is especially crucial,” Wood notes. “A will can specify who will be appointed guardian of your children should something happen to you.”
If a person of one’s choice is not appointed, the decision will ultimately go to a court, and their criteria for who will make an appropriate guardian could differ wildly from one’s own. “This can lead to a lengthy and costly legal battle that can further traumatize your children,” Wood explains.
Unnecessary taxes and fees
Additionally, when someone dies without a will, their estate may be subject to unnecessary taxes and fees. Their estate will go to probate, where courts will appoint an executor to distribute their assets.
“In Illinois and many other states, when there is no will, the court will require a bond to ensure the executor follows the law and distributes the assets correctly,” Wood explains. “This bond is an insurance policy essentially to insure the estate and heirs against malfeasance by the executor or administrator.”
One potentially substantial fee that can be avoided is the probate bond. In many instances when the will waives the bond, the estate will save more than the cost of drafting the will.
“This means some of your loved ones may be on the hook for these fees and taxes incurred,” Wood says. “The executor’s fees alone can be substantial and eat into any money any beneficiaries would possibly receive, and if your estate is subject to estate taxes, your beneficiaries may have to pay a significant amount of money to the government.”
Your business may be affected
If one owns a business, dying without a will can have especially dire consequences. “Your business could be forced to go through probate, which often leads to lengthy legal battles and financial losses,” Wood observes.
The unnecessary taxes and fees Wood previously discussed can also hit one’s business. As such, all business owners should also have a clear succession plan within their wills to ensure that either passing on or closing their business goes smoothly after their death.
You could leave loved ones without financial support
If someone is the sole breadwinner in their family, dying without a will could leave them completely without financial support. “While an estate is in probate, the deceased’s family may suffer immediate financial instability,” says Wood. “Creating an estate plan with a life insurance policy can ensure that your loved ones are financially supported even after your death.”
Death is a traumatic event for families and loved ones, but according to recent studies, roughly two-thirds of Americans either don’t have an up-to-date will or have no will at all. However, those same studies also show that higher inflation is causing more Americans to consider estate planning. Younger Americans are also 10% more likely to have a will or estate plan than in 2020, largely due to the influence of the COVID-19 pandemic.
Whatever the impetus may be, it seems that more people are realizing the importance of having a will and planning for what will happen once they pass away. As they continue to learn about the value of estate planning, attorneys like John Wood will be there to guide them through creating wills and making sound plans for the future.
Business
Revolutionizing Single-Cell RNA-seq With Automated Cell Counters: Insights From Logos Biosystems
Despite its relative newness, single-cell RNA sequencing (scRNA-seq) has become an essential component of modern biological research.
It can be used to characterize abnormal cell populations, discover and analyze rare cell cellular map networks, and discover subtle yet notable heterogeneities.
scRNA-seq has come a long way since its origins in next-generation sequencers from the late 1990s. While traditional sequencing methods measure a bulk of a cell population to determine its “average genome,” scRNA-seq is significantly more precise. It locates and extracts genomes from individual cells, using each cell to tell part of the genetic story of a greater whole.
Although single-cell sequencing provides valuable information, the process has several drawbacks depending on the method used.
For example, Laser Capture Microdissection (LCM) uses a laser to isolate target cells from a complete solid tissue sample located on a microscope slide. This approach is quick, reliable, and also usable on intact tissues, but it requires the user to identify target cells through visual inspection of their morphology. Cells can also be damaged in the process.
Other methods, like Magnetic-Activated Cell Sorting (MACS) or Fluorescence-Activated Cell Sorting (FACS), come with positives and negatives. Regardless of the approach, advancements in single-cell sequencing technology require significant time and investment, making access to newer and more efficient technologies a barrier to progress.
Overcoming Obstacles With Technological Advancement
When manually counting cells in scRNA-seq analysis, adequately going through each cell can take a huge amount of time and resources. This process also has a high margin of error, sometimes making it difficult to justify the effort.
Moreover, when cell counts are inaccurate for scRNA-seq analysis, overall data quality becomes less reliable, making the research outcomes less reliable and further exacerbating the original issues of time and cost.
With so much time and capital going toward this research, the data it produces should be worthwhile. However, the quality of the data ultimately relies on the quality of the sample before processing, which is where Logos Biosystems and their LUNA-FX7 Automated Cell Counter come in.
Enhancing Research Capabilities
Logos Biosystems is a leader in automated cell counting technology and scRNA-seq analysis and is known for developing the award-winning LUNA Cell Counter family.
Founded in 2008, the company has lived up to its motto of “seeing beyond the cell” by working to improve human health through imaging solutions that help researchers gather quality data in a timely fashion.
Their LUNA series of cell counters specializes in improving research accuracy and efficiency by allowing scientists to spend less time dealing with the monotony of cell counting and more time making valuable observations and implementing solutions.
The LUNA-FX7 Automated Cell Counter gives precise and reliable cell counts. It improves the quality of scRNA-seq analysis and takes less time than other automated counters.
This device has many invaluable features, such as increased size for sample throughput, an expanded cell concentration range, built-in QC software, validation slides for fluorescence, and brightfield to allow for daily QC monitoring and reporting.
Incorporating an automated cell counter like the LUNA-FX7 more broadly in scRNA-seq would improve research outcomes and accelerate scientific discoveries. Having machines take care of menial tasks frees up time for scientists and researchers to use their critical and creative thinking skills to push progress in their respective fields forward in ways machines couldn’t do alone.
Applications for automated cell counting technology are almost limitless, including research into developmental studies, immunology, oncology, neurobiology, diabetes, microbiology, and much more. Being able to quickly and precisely profile, identify, classify, and discover rare or new cell types from across the human body allows greater insight into these disciplines and what they can do for human health and growth.
The exciting future of single-cell RNA sequencing lies in the seamless integration of these automated technologies. As they become more widely adopted, they will pave the way for more innovative discoveries that could shape the understanding of biology and medicine. With technologies like Logos Biosystems’ LUNA-FX7, the question of whether the scientific community can see transformative discoveries is now mute as it continues to work to enhance precision and efficiency in cell evaluation, which is vital for scRNA-seq experiments to be successful to not only advance science but also improve human health and well-being on a global scale.
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