Health

Study Suggests Maintaining Klotho Protein Levels Protects Against ALS-Related Nerve Degeneration

Published

4 years ago

March 26, 2021

Amyotrophic lateral sclerosis, also known as ALS or Lou Gherig’s Disease after the famous baseball player who was forced to retire after experiencing the disease, is a fatal neurodegenerative disease. The medical term for ALS accurately describes the effects the disease has on patients. Amyotrophic refers to three root terms: a meaning “no,” myo meaning “muscle,” and trophic meaning nourishment, all of which combine to indicate that the condition leads to no nourishment of muscle tissue and atrophy, or wasting away, of the affected tissue. Lateral indicates the upper and lower areas of the spinal cord that lead to muscle atrophy, and sclerosis refers to the hardening and scarring of the affected regions.

In ALS, motor neurons that provide an essential connection between the brain and spinal cord and the rest of the body degenerate or deteriorate rapidly. When the motor neurons eventually die, the brain can no longer cause or control muscle movement, leading to their eventual atrophy. Soon after, individuals can experience partial or total paralysis of voluntary muscles, leading to an inability to control muscle movement, speak, eat, and even breathe. The average life expectancy after receiving an ALS diagnosis is between three and five years.

Lack of Available Treatments

Currently, there is no cure for ALS. While familial, or inherited, ALS accounts for some cases of the disease, nearly 95% of cases occur sporadically, without any known genetic precursor.

In an effort to find a potential preventive treatment for ALS and other neurodegenerative diseases, researchers at Boston University’s School of Medicine have turned to study biological models that simulate neurodegenerative conditions. As a result, scientists have identified a certain protein that appears to serve a unique, beneficial purpose in protecting the brain from the mechanisms of ALS.

Klotho Protein

In Boston University’s School of Medicine laboratory model, researchers identified an anti-aging protein called klotho protein that showed neuroprotective effects. In fact, increasing klotho protein levels reduced neurological deficits in experimental models of both Alzheimer’s Disease and multiple sclerosis (MS). Researchers then posited that klotho protein increases may aid in protecting the brain against other neurodegenerative diseases, as well.

In a subsequent study on a laboratory model, klotho protein provided similar neuroprotective effects against ALS. Klotho protein was shown to reduce ALS-associated neurological deficits, thus providing a potential decrease in the manifestation of symptoms. In conjunction with the presence of anti-inflammatory brain cells called microglia, klotho protein shows potential to protect the brain against inflammation, degeneration, and motor neuron loss.

Future Implications

Klotho protein therapy, along with other activities that increase klotho levels, have been shown to potentially prolong the life of an ALS patient by as much as 300 days. Further, increasing klotho levels appears to improve quality of life by reducing ALS symptoms in patients who have already discovered the disease.

While the klotho protein has long shown benefits for other neurodegenerative diseases, this new information provides hope and potential therapeutic applications for the thousands of patients currently suffering from ALS.

Resources:

https://www.eurekalert.org/pub_releases/2019-06/buso-pop062719.php
https://link.springer.com/article/10.1007/s12031-019-01356-2
https://www.als.org/understanding-als/what-is-als

Health

Finding Your Best Fit: Are GLP-1 Medications Right for Your Weight Loss Journey?

Published

12 hours ago

July 2, 2025

Michelle Langton

Over the past few years, a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists has been gaining attention, not only for treating type 2 diabetes but also in the field of weight management.

With obesity affecting “at least one in five adults (20%) in each U.S. state,” according to the CDC, many individuals are seeking effective solutions that can complement diet and exercise. Two of the most discussed options are GLP-1 injections for weight loss and GLP-1/GIP for weight loss, both of which have shown promising results.

However, deciding if these medications are right for you isn’t a one-size-fits-all process; it’s essential to determine if GLP-1s are right for you to get you to be your best self in 2025. SimpleFixRx — a healthcare service dedicated to personalized options — can help you explore GLP-1s therapy as part of your 2025 broader health plan.

Understanding GLP-1 receptor agonists

GLP-1 receptor agonists were initially designed to help regulate blood sugar in individuals with type 2 diabetes by mimicking a hormone that controls insulin secretion, slows digestion, and reduces appetite. The recent spotlight on GLP-1 injectors for weight loss and GLP-1/ GIP for weight loss stems from studies showing that these medications can help many people achieve significant, sustained weight loss — often in the 10-15 percent range or more of their body weight — when paired with healthier eating habits and increased physical activity.

Key benefits:

Enhanced blood sugar control: For individuals with type 2 diabetes, these medications can significantly lower hemoglobin A1C levels.

Appetite regulation: By slowing gastric emptying and impacting appetite signals, GLP-1s can help reduce unhealthy food cravings.

Possible cardiovascular benefits: Some research suggests that certain GLP-1s may offer heart-protective effects, reducing the risk of cardiac events.

Who can benefit from GLP-1?

GLP-1 receptor agonists have emerged as a promising option for individuals facing various metabolic and weight-related challenges. Whether you’re dealing with type 2 diabetes or seeking a meaningful way to jump-start weight loss, therapies like GLP-1/ GIP for weight loss and GLP-1 injections for weight loss could help bridge the gap where traditional diet and exercise might fall short.

Individuals with type 2 diabetes

GLP-1s remain a staple in controlling high blood sugar for patients who’ve struggled with traditional oral medications or lifestyle measures alone. If you have type 2 diabetes, speak with your healthcare provider to see if adding a GLP-1 might improve your overall management plan.

Those with obesity or weight-related health concerns

If your body mass index (BMI) is 30 or above — or you’re overweight (BMI 25–29.9) and have additional complications like prediabetes, hypertension, or high cholesterol — GLP-1s might be a strong consideration. The appetite-suppressing effects often help jump-start weight loss.

People seeking a catalyst for lifestyle changes

Even if you haven’t succeeded with traditional diets or exercise routines, medications such as GLP-1/ GIP for weight loss or GLP-1 injections for weight loss may help you regain momentum. Still, a commitment to long-term lifestyle improvements — such as more balanced eating and regular physical activity — is vital to achieving the best results.

Patients with hard-to-control metabolic factors

Some people face genetic or metabolic hurdles that make weight management exceptionally challenging. GLP-1s can help bridge that gap, providing extra support where willpower and standard lifestyle interventions might not suffice on their own.

By combining medical guidance, like that from the experts of SimpleFixRx, with regular follow-ups and a commitment to healthier habits, eligible patients may find these therapies to be a game-changer in achieving sustainable weight management and better overall health.

GLP Squared

Some compound pharmacies are now combining options for GLP medications, allowing for the microdosing of a combination of GLP and GLP1/GIP. Microdosing has numerous benefits for patients, including reduced nausea, a more steady release of medication, and decreased inflammation, among others. SimpleFix does offer GLP squared, and it is less expensive than GLP1/ GIP alone.

The SimpleFixRx approach

SimpleFixRx specializes in providing personalized healthcare solutions, including access to GLP-1 therapies, through a convenient, patient-centered platform. Their team of licensed healthcare providers works closely with patients to:

Assess eligibility: SimpleFixRx professionals review each patient’s medical history, lifestyle habits, and specific health goals to determine if GLP-1 therapy is appropriate.

Offer comprehensive care plans: Beyond prescribing medications, SimpleFixRx aims to create a holistic approach that includes nutritional guidance and exercise plans, ensuring GLP-1 therapy is supported by healthier daily habits.

Monitor progress: Through regular follow-up appointments, patients can collaborate with the SimpleFixRx team to fine-tune their regimen and address any side effects or emerging concerns.

Potential side effects and considerations

While GLP-1s offer noteworthy benefits, they aren’t free of potential drawbacks. The most frequently reported side effects include nausea, diarrhea, and, in some cases, vomiting — especially when first beginning treatment — but these often ease as your body adjusts. Other, more serious risks include pancreatitis or gallbladder issues, though these are generally less common.

Your medical history and personal goals should guide any decision to start GLP-1 therapy. Certain gastrointestinal or thyroid conditions, for instance, could make these medications less suitable. Women who are or might become pregnant also need specialized guidance, as safety data for pregnancy remains limited.

Making the decision with SimpleFixRx

Dr. Garrett H. Garner, M.D., F.A.C.O.G., a board-certified OB/GYN with over two decades of experience in North Texas, highlights the importance of individualized care. “We take the time to review each patient’s medical history, dietary habits, and long-term health objectives. Medications like GLP-1/ GIP or GLP-1 can be game-changers — but they work best within a broader strategy that includes nutrition, exercise, and regular follow-up.”

Before you opt for any GLP-1 medication, consider asking your healthcare provider or a service like SimpleFixRx these five questions:

“Am I a good candidate for GLP-1s based on my health profile?”
“How will this therapy interact with other treatments or conditions I have?”
“What lifestyle changes, if any, should I implement to maximize the benefits?”
“Which medication — GLP-1/ GIP vs. GLP-1 — would best suit my needs?”
“How often should I schedule follow-up appointments to assess progress and adjust my treatment plan?”

By partnering with a dedicated healthcare service like SimpleFixRx, you can gain access to expert guidance, personalized care plans, and ongoing support — all crucial components to long-term success.

These therapies are tools, not magic solutions, as sustainable progress often hinges on a combination of effective medication, mindful eating, regular physical activity, and consistent medical oversight. However, with the proper support structure and commitment, GLP-1 medications can be a transformative part of your journey toward better health.