Health

Study Suggests Maintaining Klotho Protein Levels Protects Against ALS-Related Nerve Degeneration

Published

5 years ago

March 26, 2021

Amyotrophic lateral sclerosis, also known as ALS or Lou Gherig’s Disease after the famous baseball player who was forced to retire after experiencing the disease, is a fatal neurodegenerative disease. The medical term for ALS accurately describes the effects the disease has on patients. Amyotrophic refers to three root terms: a meaning “no,” myo meaning “muscle,” and trophic meaning nourishment, all of which combine to indicate that the condition leads to no nourishment of muscle tissue and atrophy, or wasting away, of the affected tissue. Lateral indicates the upper and lower areas of the spinal cord that lead to muscle atrophy, and sclerosis refers to the hardening and scarring of the affected regions.

In ALS, motor neurons that provide an essential connection between the brain and spinal cord and the rest of the body degenerate or deteriorate rapidly. When the motor neurons eventually die, the brain can no longer cause or control muscle movement, leading to their eventual atrophy. Soon after, individuals can experience partial or total paralysis of voluntary muscles, leading to an inability to control muscle movement, speak, eat, and even breathe. The average life expectancy after receiving an ALS diagnosis is between three and five years.

Lack of Available Treatments

Currently, there is no cure for ALS. While familial, or inherited, ALS accounts for some cases of the disease, nearly 95% of cases occur sporadically, without any known genetic precursor.

In an effort to find a potential preventive treatment for ALS and other neurodegenerative diseases, researchers at Boston University’s School of Medicine have turned to study biological models that simulate neurodegenerative conditions. As a result, scientists have identified a certain protein that appears to serve a unique, beneficial purpose in protecting the brain from the mechanisms of ALS.

Klotho Protein

In Boston University’s School of Medicine laboratory model, researchers identified an anti-aging protein called klotho protein that showed neuroprotective effects. In fact, increasing klotho protein levels reduced neurological deficits in experimental models of both Alzheimer’s Disease and multiple sclerosis (MS). Researchers then posited that klotho protein increases may aid in protecting the brain against other neurodegenerative diseases, as well.

In a subsequent study on a laboratory model, klotho protein provided similar neuroprotective effects against ALS. Klotho protein was shown to reduce ALS-associated neurological deficits, thus providing a potential decrease in the manifestation of symptoms. In conjunction with the presence of anti-inflammatory brain cells called microglia, klotho protein shows potential to protect the brain against inflammation, degeneration, and motor neuron loss.

Future Implications

Klotho protein therapy, along with other activities that increase klotho levels, have been shown to potentially prolong the life of an ALS patient by as much as 300 days. Further, increasing klotho levels appears to improve quality of life by reducing ALS symptoms in patients who have already discovered the disease.

While the klotho protein has long shown benefits for other neurodegenerative diseases, this new information provides hope and potential therapeutic applications for the thousands of patients currently suffering from ALS.

Resources:

https://www.eurekalert.org/pub_releases/2019-06/buso-pop062719.php
https://link.springer.com/article/10.1007/s12031-019-01356-2
https://www.als.org/understanding-als/what-is-als

Health

Choosing the Right Pilates Reformer: A Practical Buyer’s Guide

Published

4 hours ago

December 22, 2025

Michelle Langton

Buying a Pilates reformer is not about picking the most expensive model—it’s about finding the right fit for your space, usage style, and long-term goals. Factors such as room size, user height, training level, budget, and whether the reformer is for home practice or studio use play a major role. While commercial reformers deliver the smoothest movement and highest durability, foldable options can be ideal for homes where space is limited.

Top Choice for Professional Studio Performance

For those seeking premium, studio-grade quality, the PersonalHour Nano Elite Plus stands out as a leading option. Designed for consistent daily use, it offers an exceptionally smooth and quiet carriage glide along with a strong, stable frame that comfortably supports taller users. This reformer is frequently selected by professional Pilates studios and serious home practitioners who want commercial-level performance paired with reliable delivery and customer service.

Established Names in Commercial Pilates Studios

The Balanced Body Allegro 2 has long been a staple in Pilates studios worldwide. Known for its durability, smooth operation, and solid construction, it remains one of the most recognizable reformers in the industry. Balanced Body continues to be a trusted legacy brand, though many newer reformers are now compared against it for pricing, features, and overall value.

A Balanced Option for Home and Professional Use

The Merrithew SPX Max is often recommended for users who want professional-grade equipment without paying top-tier studio prices. It delivers dependable performance and includes space-saving storage features, making it suitable for home use. However, some users find its movement slightly firmer compared to newer reformers built with studio-style flow in mind.

Best Space-Saving Reformer Without Compromising Quality

When floor space is a concern, the PersonalHour Janet 2.0 is one of the strongest folding reformers available. Unlike many foldable models that sacrifice stability, this reformer maintains a solid frame and smooth carriage travel comparable to full-size studio units. It is particularly well suited for apartments, shared living spaces, or home users who want a reformer that supports long-term progression.

Best Folding Pilates Reformer for Small Spaces

Beginner-Friendly and Budget-Conscious Alternatives

Entry-level and compact reformers, such as AeroPilates models, can be a good starting point for beginners or those practicing occasionally. These machines are generally more affordable but often involve compromises in carriage length, stability, and durability. As a result, they may not be ideal for advanced exercises or long-term use.

What to Look for Before You Buy

Before choosing a Pilates reformer, it’s important to evaluate the following aspects:

Carriage performance: Smooth, quiet movement with balanced spring tension
Available space: Full-length reformer versus folding or stackable designs
User fit: Longer frames provide better comfort for taller users
Adjustability: Footbars, jump boards, and accessory compatibility
After-sales support: Clear warranty coverage and responsive service

Final Takeaway

If your goal is studio-level performance, the PersonalHour Nano Elite Plus is a standout choice. For homes with limited space, the PersonalHour Janet 2.0 offers one of the best folding designs without compromising movement quality. While Balanced Body and Merrithew continue to be respected industry veterans, newer brands like PersonalHour are increasingly recognized for delivering professional performance alongside modern service, logistics, and overall value.

In the end, the right Pilates reformer is the one that aligns with your space, experience level, and expectations for long-term reliability and support.