Tech
Eric Leire: How Biotechnology Can Contribute To Longevity Research
Dr. Eric Leire, MD, MBA, is the CEO and Founder of GenFlow Biosciences. He has an impressive background in the biotechnology and gene therapy sector. Furthermore, Eric has a plethora of remarkable experience in the pharmaceutical industry, having held Pfizer, Schering Plough, and Pharmacia posts. His success has also translated into academic research, where he has held a research position at Harvard University.
In addition, his career has soared throughout the biotechnology industry, being the CEO of several private and public biotech companies. He is also the inventor of several patents and serves on the board of several biotechnology companies, such as Pherecydes (ALPHE.PA), Immunethep (developing a Covid vaccine), Inhatarget, and BSIM.
With the Biotech sector forecast to grow close to $2.5 trillion by 2028 – the financial benefits are straightforward and the moral importance to serve societal needs. In addition, research into longevity and healthy aging have progressed rapidly in recent years. We chatted with Eric, who explains how developments in the biotechnology sector can aid the longevity research process.
“Many US biotech companies shifted their research focus to improving longevity. However, only a few European biotech companies are working on a science-based development of therapeutic interventions that could delay the aging process.”
He continues, “Our company is interested in identifying the genetic and molecular pathways underpinning the aging process.” Specifically, Genflow Biosciences’ work is based on the fact that DNA repair plays a crucial role in determining an organism’s lifespan. As humans and other mammals grow older, our DNA is more and more prone to breaks. GenFlow intends to provide extra copies of a gene involved in DNA repair called SIRT6 and, more specifically, a variant of the SIRT6 found in centenarians. The additional copies of centenarian SIRT6 will improve the ability to repair DNA damage.
The feasibility of gene transfer to patients was demonstrated around 30 years ago and these methods have improved substantially. As a result, many commercial gene therapy candidates are now focussing on gene therapy for multiple diseases.
Scientists now can inject more efficient AAVs that can express a transgene such as SIRT6 into specific cells. Like other viruses, the tropism of an AAV for particular cells is controlled by the particular interaction between the proteins of its capsid (the protein shell enclosing the AAV genetic material) and the receptors of the targeted cells. In the last decade, there has been a tremendous advance in the ability to design novel, highly efficient AAVs that can target specific cells or organs.
Having a toolbox of enhanced AAVs is an important step; however, to develop an effective SIRT6 gene delivery, we also needed an understanding of the potential immunity to AAVs. A pre-existing barrier to AAV gene delivery stems from our natural exposure to AAV, resulting in a possible pre-existing humoral and cellular immunity to AAVs. Even a highly efficient and specific AAV delivering an ideal transgene (such as SIRT6) means nothing if an immune response prevents the AAV from reaching the appropriate cells. Therefore, it is critical when translating AAV gene delivery for clinical applications first to determine whether the patient has pre-existing immunity to AAV and then mitigate the development of potentially damaging immune responses when the gene is delivered intravenously. Fortunately, several studies have assessed the immune response to AAV-mediated gene therapy in both pre-clinical models and human patients. Overcoming pre-existing immunity is not trivial, but we now have strategies to enable AAV treatment without triggering immunity.
Eric believes that GenFlow’s contribution to advancing the understanding of anti-AAV immunity in our pre-clinical program. During clinical trials will help not only the development of our product but will also participate in the development of other safe and highly efficacious AAV therapies for other diseases such as neurodegenerative diseases, cardiovascular diseases, and cancer.
Tech
AI in Placemaking: How ERA-co is Using Smarter Data to Build Better Cities
ERA-co is exploring new ways to apply AI in urban design, utilizing data-driven tools to support more thoughtful and responsive placemaking. Rather than replacing human insight, the firm sees artificial intelligence as a partner — one that can enhance how designers understand and shape the spaces where people live, move, and connect.
This approach isn’t about flashy tech or fully automated cities. It’s about asking better questions, revealing patterns we might otherwise miss, and using that knowledge to make decisions rooted in real-world behavior. For ERA-co, AI becomes most valuable when it helps clarify how a city works, layer by layer, so design teams can create places that are not only efficient but also livable and meaningful.
Understanding complexity before optimization
Before talking about smart tools or predictions, ERA-co begins with a foundational question: “What kind of problem is a city?” Nicolas Palominos, Head of Urban Design and Strategy R&D at ERA-co, references the work of Jane Jacobs to frame this.
“As Jacobs reminds us, cities exhibit complex system behavior, where multiple elements vary simultaneously, in subtle interconnected ways,” Palominos explains. “AI can augment our understanding of these parameters to design better places with optimized social benefit.”
According to Palominos, that kind of social benefit can take many forms. It might involve modeling a housing system that supports proximity-based living, such as the concept of the “15-minute city,” or applying predictive analytics to anticipate and respond to events like floods, heatwaves, or infrastructure failures.
ERA-co doesn’t use AI to chase efficiency for its own sake. Instead, the firm uses it to gain a more comprehensive understanding and a clearer picture of a place’s behavior.
Data that matches people, not just places
Not all data is created equal. When it comes to placemaking, ERA-co prioritizes what Palominos calls “spatial and temporal granularity,” which entails not only examining how a space functions on a map but also understanding how people interact with it over time — from hour to hour, and season to season.
“The most valuable data are those with the greatest spatial and temporal granularity for observing people and urban environments,” Palominos says. “Video footage, mobile data, street view imagery, and satellite imagery enable a deeper understanding of how different groups of people perceive and use public space.”
One recent ERA-co proof-of-concept used AI to assess how people visually perceive streetscapes, analyzing elements like enclosure, complexity, and human scale. These insights informed more nuanced design strategies that align with local behaviors, not just abstract zoning plans.
This level of detail matters because even small design shifts can have ripple effects on how people move, feel, and gather. With AI, ERA-co isn’t just tracking patterns but learning from them.
ERA-co’s AI mobility work: Subtle shifts, broader benefits
Some of the clearest applications of AI can be seen in mobility — how people and goods move through cities. It’s here that ERA-co sees measurable gains in both function and experience.
“AI-driven fleet optimization balances supply and demand in bus services and bike-share systems,” Palominos says. “On the consumer side, it streamlines courier and delivery services through route optimization.”
These systems don’t operate in isolation. When they’re better coordinated, they can relieve pressure on road networks, reduce congestion, and lower energy use. But what makes ERA-co’s approach different is that it doesn’t stop at logistics. It examines how those systems impact the daily lives of people who live in and move through a place.
The limits of AI and the role of design judgment
As much as AI can help us see more, ERA-co is careful not to let it make the final call. Cities are more than just systems — they’re layered with memory, identity, and human connection. And not everything meaningful can be measured.
“There have been cases where AI insights pointed us in one direction, but human judgment and cultural understanding led us another way,” Palominos notes.
Sometimes a place functions well on paper, but feels hollow in practice. Other times, a community gathering space might disrupt traffic flow, yet provide invaluable support for social well-being.
This is where design intuition becomes critical. ERA-co uses AI to inform, not dictate, the design process.
Planning for a future in flux
Looking ahead, ERA-co sees AI playing a growing role in helping cities adapt — not just to top physical threats like climate change, but also to slower, less visible shifts in how people live and connect.
“AI will amplify our understanding of how cities function through enhanced spatial representation and analysis, informing better human decision-making,” Palominos says. He references recent findings (like an MIT study showing people walk faster and linger less in public spaces) as examples of trends that would have been hard to anticipate without AI.
Still, the goal isn’t to automate responses to those behaviors. It’s using those insights to reimagine what kinds of public spaces people may need in the future, especially as patterns of connection and isolation shift.
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