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Eric Leire: How Biotechnology Can Contribute To Longevity Research

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Dr. Eric Leire, MD, MBA, is the CEO and Founder of GenFlow Biosciences. He has an impressive background in the biotechnology and gene therapy sector. Furthermore, Eric has a plethora of remarkable experience in the pharmaceutical industry, having held Pfizer, Schering Plough, and Pharmacia posts. His success has also translated into academic research, where he has held a research position at Harvard University.

In addition, his career has soared throughout the biotechnology industry, being the CEO of several private and public biotech companies. He is also the inventor of several patents and serves on the board of several biotechnology companies, such as Pherecydes (ALPHE.PA), Immunethep (developing a Covid vaccine), Inhatarget, and BSIM. 

With the Biotech sector forecast to grow close to $2.5 trillion by 2028 – the financial benefits are straightforward and the moral importance to serve societal needs. In addition, research into longevity and healthy aging have progressed rapidly in recent years. We chatted with Eric, who explains how developments in the biotechnology sector can aid the longevity research process.

“Many US biotech companies shifted their research focus to improving longevity.  However, only a few European biotech companies are working on a science-based development of therapeutic interventions that could delay the aging process.”

He continues, “Our company is interested in identifying the genetic and molecular pathways underpinning the aging process.” Specifically, Genflow Biosciences’ work is based on the fact that DNA repair plays a crucial role in determining an organism’s lifespan.  As humans and other mammals grow older, our DNA is more and more prone to breaks.  GenFlow intends to provide extra copies of a gene involved in DNA repair called SIRT6 and, more specifically, a variant of the SIRT6 found in centenarians.  The additional copies of centenarian SIRT6 will improve the ability to repair DNA damage.

The feasibility of gene transfer to patients was demonstrated around 30 years ago and these methods have improved substantially. As a result, many commercial gene therapy candidates are now focussing on gene therapy for multiple diseases.

Scientists now can inject more efficient AAVs that can express a transgene such as SIRT6 into specific cells. Like other viruses, the tropism of an AAV for particular cells is controlled by the particular interaction between the proteins of its capsid (the protein shell enclosing the AAV genetic material) and the receptors of the targeted cells. In the last decade, there has been a tremendous advance in the ability to design novel, highly efficient AAVs that can target specific cells or organs.

Having a toolbox of enhanced AAVs is an important step; however, to develop an effective SIRT6 gene delivery, we also needed an understanding of the potential immunity to AAVs.  A pre-existing barrier to AAV gene delivery stems from our natural exposure to AAV, resulting in a possible pre-existing humoral and cellular immunity to AAVs.  Even a highly efficient and specific AAV delivering an ideal transgene (such as SIRT6) means nothing if an immune response prevents the AAV from reaching the appropriate cells. Therefore, it is critical when translating AAV gene delivery for clinical applications first to determine whether the patient has pre-existing immunity to AAV and then mitigate the development of potentially damaging immune responses when the gene is delivered intravenously. Fortunately, several studies have assessed the immune response to AAV-mediated gene therapy in both pre-clinical models and human patients.  Overcoming pre-existing immunity is not trivial, but we now have strategies to enable AAV treatment without triggering immunity.

Eric believes that GenFlow’s contribution to advancing the understanding of anti-AAV immunity in our pre-clinical program. During clinical trials will help not only the development of our product but will also participate in the development of other safe and highly efficacious AAV therapies for other diseases such as neurodegenerative diseases, cardiovascular diseases, and cancer.

From television to the internet platform, Jonathan switched his journey in digital media with Bigtime Daily. He served as a journalist for popular news channels and currently contributes his experience for Bigtime Daily by writing about the tech domain.

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What Is a Cloud Phone? Features, Benefits, and How to Choose the Best

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Many entrepreneurs today look for ways to better communication in their companies. Maybe you are one of them. This article will make you understand what cloud phone is. Many phone systems are available to small and big companies today. A cloud-based system is one of them. This system is reliable, has a low cost, and has many business-friendly features.

What Is a Cloud Phone?

A cloud phone, also known as a cloud-based phone system, is a phone that allows the user to make calls over the internet. Cloud phones are entirely different from traditional phones that use copper wire to make a connection. Instead, all you need is to have a stable network to access the system.

Features Found on a Cloud Phone

Customers highly prefer cloud phone systems because of the features found in the package. Here are some of the significant features of a cloud-based phone system:

Voicemail

The voice mail feature converts voicemails into text. So you don’t need to listen to every voice mail message. Instead, voicemail transcription helps you read through voicemail messages and grab essential particulars.

Call Forwarding

This feature helps the user direct a call to the desired party. In addition, it makes communication more manageable because it gets to the desired destination.

Auto Replies

In a cloud-based phone system, having your device in hand to reply to a message is not a must. Responses can be made to the sender automatically based on the destined set-off, even when you are far from your device. This makes your client get instant replies when they text.

MMS Support

A multimedia messaging service is used to send multimedia content. For example, it can send GIFS, videos, audio files, and messages with more than 160 characters. This enchants customers who get to view the content.

Scalable Virtual Number Options

The scalable number option is another significant feature of a cloud-based phone system. Growing businesses need more team members; thus, more numbers are required for additional members. You can add more numbers to the account with the scalable number option.

What are the Benefits of Cloud Phones?

Below are the benefits of a cloud-based phone.

Low Cost

The cost of using a cloud phone is low compared to the traditional phone system. The pricing depends on the features and the number of connected lines.

Reliability

Having a reliable line is key to any business. Data stored in the cloud cannot be lost once there is a power failure or other problems associated with the system. In addition, the cloud ensures that the data is backed up and stored in a safe location. Finally, assessing your data keeps you at work, thus minimizing any downtime and increasing productivity.

Scalability and Control

With a traditional phone system, you will find it hard to add a user. But with the cloud phone system, you add a user and are ready to go. Furthermore, the cloud phone system allows you to only pay and use what you need.

Conclusion

When choosing the right service provider to engage with, you should consider reliability, user-friendliness, cost, customer support, and value for money. With all these considerations and sound research, there is no doubt that you will land the best cloud-based phone system that suits your company.

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