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Eric Leire: How Biotechnology Can Contribute To Longevity Research




Dr. Eric Leire, MD, MBA, is the CEO and Founder of GenFlow Biosciences. He has an impressive background in the biotechnology and gene therapy sector. Furthermore, Eric has a plethora of remarkable experience in the pharmaceutical industry, having held Pfizer, Schering Plough, and Pharmacia posts. His success has also translated into academic research, where he has held a research position at Harvard University.

In addition, his career has soared throughout the biotechnology industry, being the CEO of several private and public biotech companies. He is also the inventor of several patents and serves on the board of several biotechnology companies, such as Pherecydes (ALPHE.PA), Immunethep (developing a Covid vaccine), Inhatarget, and BSIM. 

With the Biotech sector forecast to grow close to $2.5 trillion by 2028 – the financial benefits are straightforward and the moral importance to serve societal needs. In addition, research into longevity and healthy aging have progressed rapidly in recent years. We chatted with Eric, who explains how developments in the biotechnology sector can aid the longevity research process.

“Many US biotech companies shifted their research focus to improving longevity.  However, only a few European biotech companies are working on a science-based development of therapeutic interventions that could delay the aging process.”

He continues, “Our company is interested in identifying the genetic and molecular pathways underpinning the aging process.” Specifically, Genflow Biosciences’ work is based on the fact that DNA repair plays a crucial role in determining an organism’s lifespan.  As humans and other mammals grow older, our DNA is more and more prone to breaks.  GenFlow intends to provide extra copies of a gene involved in DNA repair called SIRT6 and, more specifically, a variant of the SIRT6 found in centenarians.  The additional copies of centenarian SIRT6 will improve the ability to repair DNA damage.

The feasibility of gene transfer to patients was demonstrated around 30 years ago and these methods have improved substantially. As a result, many commercial gene therapy candidates are now focussing on gene therapy for multiple diseases.

Scientists now can inject more efficient AAVs that can express a transgene such as SIRT6 into specific cells. Like other viruses, the tropism of an AAV for particular cells is controlled by the particular interaction between the proteins of its capsid (the protein shell enclosing the AAV genetic material) and the receptors of the targeted cells. In the last decade, there has been a tremendous advance in the ability to design novel, highly efficient AAVs that can target specific cells or organs.

Having a toolbox of enhanced AAVs is an important step; however, to develop an effective SIRT6 gene delivery, we also needed an understanding of the potential immunity to AAVs.  A pre-existing barrier to AAV gene delivery stems from our natural exposure to AAV, resulting in a possible pre-existing humoral and cellular immunity to AAVs.  Even a highly efficient and specific AAV delivering an ideal transgene (such as SIRT6) means nothing if an immune response prevents the AAV from reaching the appropriate cells. Therefore, it is critical when translating AAV gene delivery for clinical applications first to determine whether the patient has pre-existing immunity to AAV and then mitigate the development of potentially damaging immune responses when the gene is delivered intravenously. Fortunately, several studies have assessed the immune response to AAV-mediated gene therapy in both pre-clinical models and human patients.  Overcoming pre-existing immunity is not trivial, but we now have strategies to enable AAV treatment without triggering immunity.

Eric believes that GenFlow’s contribution to advancing the understanding of anti-AAV immunity in our pre-clinical program. During clinical trials will help not only the development of our product but will also participate in the development of other safe and highly efficacious AAV therapies for other diseases such as neurodegenerative diseases, cardiovascular diseases, and cancer.

From television to the internet platform, Jonathan switched his journey in digital media with Bigtime Daily. He served as a journalist for popular news channels and currently contributes his experience for Bigtime Daily by writing about the tech domain.

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Introducing Bitcoin Questions: The AI-Powered Platform for All Your Bitcoin Inquiries




As Bitcoin gains traction in the global economy, the need for a comprehensive and accessible source of information on the world’s leading cryptocurrency becomes increasingly evident. Enter Bitcoin Questions, the ultimate destination for all inquiries related to Bitcoin. Powered by state-of-the-art artificial intelligence technology, this platform provides accurate and reliable answers to a wide range of questions about the fascinating world of Bitcoin. In this article, we will explore the features and benefits that make Bitcoin Questions an invaluable resource for everyone, from beginners to seasoned cryptocurrency enthusiasts.

A Cutting-Edge AI-Powered Platform for Bitcoin Information

Navigating the complex landscape of Bitcoin can be challenging, especially for those who are new to the field. To address this issue, Bitcoin Questions harnesses the power of advanced AI technology to deliver precise and up-to-date information on various aspects of Bitcoin. Here’s a closer look at what you can expect from this innovative platform:

Instant Answers: Whether you have a general question about Bitcoin or a specific inquiry about transactions, wallets, or mining, Bitcoin Questions has you covered. Simply type your question into the search bar, and the platform’s AI algorithms will instantly provide you with a clear, concise, and accurate answer.

Comprehensive Knowledge Base: The platform’s AI draws from a vast and continually updated knowledge base, ensuring that users receive the most current and relevant information on any Bitcoin-related topic. From understanding basic concepts to exploring advanced trading strategies, Bitcoin Questions serves as an invaluable resource for users at all levels of expertise.

User-Friendly Interface: Bitcoin Questions boasts a clean, intuitive interface designed to facilitate seamless user experience. The platform’s straightforward layout allows users to find the information they seek quickly and efficiently, eliminating the need to sift through multiple resources or navigate complex websites.

Tailored Recommendations: As you interact with the platform, the AI technology learns from your queries and preferences, allowing it to provide personalized recommendations for further reading or exploration. This adaptive learning process ensures that users receive the most relevant information based on their individual needs and interests.

Expert-Verified Content: While the AI technology underpinning Bitcoin Questions is incredibly powerful, the platform’s creators understand the importance of human expertise. To ensure the highest level of accuracy and reliability, a team of cryptocurrency experts routinely reviews and verifies the content generated by the AI algorithms.

Dynamic Updates: The world of cryptocurrencies is in a constant state of flux, with new developments, trends, and regulations emerging regularly. Bitcoin Questions’ AI technology is designed to stay ahead of the curve, continuously updating its knowledge base to reflect the latest information and insights in the Bitcoin space.

Global Accessibility: Bitcoin Questions is available 24/7 and accessible from anywhere in the world, making it an ideal resource for users across different time zones and geographical locations. The platform’s commitment to inclusivity and accessibility ensures that anyone with an interest in Bitcoin can access reliable information when they need it.

Privacy and Security: In an age where online privacy and security are paramount, Bitcoin Questions takes these concerns seriously. The platform employs robust security measures to protect user data and ensure a safe and private browsing experience.


Bitcoin Questions stands out as a groundbreaking platform that harnesses the power of AI technology to provide users with accurate, reliable, and up-to-date information on all aspects of Bitcoin. Its user-friendly design, personalized recommendations, and expert-verified content make it an indispensable resource for anyone looking to explore and understand the complex world of cryptocurrencies. With Bitcoin Questions, you can confidently embark on your journey into the exciting realm of Bitcoin, armed with the knowledge and insights you need to succeed.

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