Health

Your Circadian Rhythm: What It Is And Why It Matters

Published

4 years ago

November 9, 2021

If you’ve ever read anything about how using your cell phone can keep you from getting a good night’s sleep or wondered why you get jet lagged when you travel, then you’ve spent at least a little time thinking about circadian rhythms. But what exactly are circadian rhythms, and why are they so important? It’s a big question with a lot to unpack.

Your Body’s Clock

A common way that scientists and writers describe your circadian rhythms is as your body’s internal or biological clock, and this is a good, basic description. Circadian rhythms consist of the many different bodily patterns that are tied to a 24-hour daily cycle.

These are physical, mental, and even behavioral, and different organ systems have their own unique expressions of these cycles. These shifts, which are largely regulated by exposure to light, especially sunlight, are most notable to the individual as hunger signals and digestion, body temperature, and alertness or fatigue.

Circadian Rhythm Disruptions

Another important factor everyone should understand about circadian rhythms is that their disruption by outside forces can lead to serious health problems. Now, a few nights of fatigue due to jet lag aren’t serious, of course, but in the long-term, dysregulation can lead to serious illnesses. And conversely, disruptions in circadian rhythms can be a sign of an underlying disorder.

As the most outwardly obvious sign of your circadian rhythms daily progression, sleep may be the most widely researched of the daily biological cycles. For example, researchers have looked carefully at sleep apnea as a cause of serious health problems.

Sleep apnea can be obstructive – meaning it’s caused by a physical blockage – or central – meaning the brain doesn’t send the signal to breathe during sleep; but in either case, it can prevent people from experiencing restful sleep, leading to significant health problems, including daytime sleepiness, problems with appetite regulation, and even an increased risk of heart disease and obesity.

Circadian Rhythms And Neurodegeneration

One of the most significant recent discoveries of note regarding circadian rhythms is the link between circadian rhythm dysfunction and neurodegenerative conditions like Alzheimer’s disease. In a study supported by the Brain Research Foundation, Dr. Ravi Allada explored the function of the circadian clock gene in fruit fly models, specifically examining its neuroprotective role. When there is a mutation in this gene, his lab concluded, the body is less able to protect itself against neurodegeneration.

Circadian Rhythms And Cancer

Another emerging area of research related to circadian rhythms is in regard to cancer risk. When the body’s normal rhythms, which include those involved in immune system function, are no longer working properly, it’s more likely that normal cellular repair systems will fail. This can lead to dangerous mutations; the body may also be less able to naturally kill cancer cells when there is a circadian rhythm disorder present.

There are many different illnesses directly and indirectly linked to circadian rhythm disorders, and work addressing these issues is still in the early stages. What has become clear, however, is that the more we know about our vital internal rhythms and how to maintain them, the better equipped we are to protect our overall health.

Health

Finding Your Best Fit: Are GLP-1 Medications Right for Your Weight Loss Journey?

Published

1 week ago

July 2, 2025

Michelle Langton

Over the past few years, a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists has been gaining attention, not only for treating type 2 diabetes but also in the field of weight management.

With obesity affecting “at least one in five adults (20%) in each U.S. state,” according to the CDC, many individuals are seeking effective solutions that can complement diet and exercise. Two of the most discussed options are GLP-1 injections for weight loss and GLP-1/GIP for weight loss, both of which have shown promising results.

However, deciding if these medications are right for you isn’t a one-size-fits-all process; it’s essential to determine if GLP-1s are right for you to get you to be your best self in 2025. SimpleFixRx — a healthcare service dedicated to personalized options — can help you explore GLP-1s therapy as part of your 2025 broader health plan.

Understanding GLP-1 receptor agonists

GLP-1 receptor agonists were initially designed to help regulate blood sugar in individuals with type 2 diabetes by mimicking a hormone that controls insulin secretion, slows digestion, and reduces appetite. The recent spotlight on GLP-1 injectors for weight loss and GLP-1/ GIP for weight loss stems from studies showing that these medications can help many people achieve significant, sustained weight loss — often in the 10-15 percent range or more of their body weight — when paired with healthier eating habits and increased physical activity.

Key benefits:

Enhanced blood sugar control: For individuals with type 2 diabetes, these medications can significantly lower hemoglobin A1C levels.

Appetite regulation: By slowing gastric emptying and impacting appetite signals, GLP-1s can help reduce unhealthy food cravings.

Possible cardiovascular benefits: Some research suggests that certain GLP-1s may offer heart-protective effects, reducing the risk of cardiac events.

Who can benefit from GLP-1?

GLP-1 receptor agonists have emerged as a promising option for individuals facing various metabolic and weight-related challenges. Whether you’re dealing with type 2 diabetes or seeking a meaningful way to jump-start weight loss, therapies like GLP-1/ GIP for weight loss and GLP-1 injections for weight loss could help bridge the gap where traditional diet and exercise might fall short.

Individuals with type 2 diabetes

GLP-1s remain a staple in controlling high blood sugar for patients who’ve struggled with traditional oral medications or lifestyle measures alone. If you have type 2 diabetes, speak with your healthcare provider to see if adding a GLP-1 might improve your overall management plan.

Those with obesity or weight-related health concerns

If your body mass index (BMI) is 30 or above — or you’re overweight (BMI 25–29.9) and have additional complications like prediabetes, hypertension, or high cholesterol — GLP-1s might be a strong consideration. The appetite-suppressing effects often help jump-start weight loss.

People seeking a catalyst for lifestyle changes

Even if you haven’t succeeded with traditional diets or exercise routines, medications such as GLP-1/ GIP for weight loss or GLP-1 injections for weight loss may help you regain momentum. Still, a commitment to long-term lifestyle improvements — such as more balanced eating and regular physical activity — is vital to achieving the best results.

Patients with hard-to-control metabolic factors

Some people face genetic or metabolic hurdles that make weight management exceptionally challenging. GLP-1s can help bridge that gap, providing extra support where willpower and standard lifestyle interventions might not suffice on their own.

By combining medical guidance, like that from the experts of SimpleFixRx, with regular follow-ups and a commitment to healthier habits, eligible patients may find these therapies to be a game-changer in achieving sustainable weight management and better overall health.

GLP Squared

Some compound pharmacies are now combining options for GLP medications, allowing for the microdosing of a combination of GLP and GLP1/GIP. Microdosing has numerous benefits for patients, including reduced nausea, a more steady release of medication, and decreased inflammation, among others. SimpleFix does offer GLP squared, and it is less expensive than GLP1/ GIP alone.

The SimpleFixRx approach

SimpleFixRx specializes in providing personalized healthcare solutions, including access to GLP-1 therapies, through a convenient, patient-centered platform. Their team of licensed healthcare providers works closely with patients to:

Assess eligibility: SimpleFixRx professionals review each patient’s medical history, lifestyle habits, and specific health goals to determine if GLP-1 therapy is appropriate.

Offer comprehensive care plans: Beyond prescribing medications, SimpleFixRx aims to create a holistic approach that includes nutritional guidance and exercise plans, ensuring GLP-1 therapy is supported by healthier daily habits.

Monitor progress: Through regular follow-up appointments, patients can collaborate with the SimpleFixRx team to fine-tune their regimen and address any side effects or emerging concerns.

Potential side effects and considerations

While GLP-1s offer noteworthy benefits, they aren’t free of potential drawbacks. The most frequently reported side effects include nausea, diarrhea, and, in some cases, vomiting — especially when first beginning treatment — but these often ease as your body adjusts. Other, more serious risks include pancreatitis or gallbladder issues, though these are generally less common.

Your medical history and personal goals should guide any decision to start GLP-1 therapy. Certain gastrointestinal or thyroid conditions, for instance, could make these medications less suitable. Women who are or might become pregnant also need specialized guidance, as safety data for pregnancy remains limited.

Making the decision with SimpleFixRx

Dr. Garrett H. Garner, M.D., F.A.C.O.G., a board-certified OB/GYN with over two decades of experience in North Texas, highlights the importance of individualized care. “We take the time to review each patient’s medical history, dietary habits, and long-term health objectives. Medications like GLP-1/ GIP or GLP-1 can be game-changers — but they work best within a broader strategy that includes nutrition, exercise, and regular follow-up.”

Before you opt for any GLP-1 medication, consider asking your healthcare provider or a service like SimpleFixRx these five questions:

“Am I a good candidate for GLP-1s based on my health profile?”
“How will this therapy interact with other treatments or conditions I have?”
“What lifestyle changes, if any, should I implement to maximize the benefits?”
“Which medication — GLP-1/ GIP vs. GLP-1 — would best suit my needs?”
“How often should I schedule follow-up appointments to assess progress and adjust my treatment plan?”

By partnering with a dedicated healthcare service like SimpleFixRx, you can gain access to expert guidance, personalized care plans, and ongoing support — all crucial components to long-term success.

These therapies are tools, not magic solutions, as sustainable progress often hinges on a combination of effective medication, mindful eating, regular physical activity, and consistent medical oversight. However, with the proper support structure and commitment, GLP-1 medications can be a transformative part of your journey toward better health.